Seven Strategic Approaches
A comprehensive framework for targeting biological aging from multiple angles
Scientific Framework
Making Complexity Actionable
The biology of aging involves thousands of interconnected processes across multiple scales—from molecules to cells to tissues to organs. Rather than being overwhelmed by this complexity, we organize aging interventions into seven strategic themes that make the field accessible and actionable.
Each strategy addresses specific hallmarks of aging identified in landmark research. Together, they form a comprehensive framework for extending healthspan.
Get the Crud Out
Remove cellular damage and waste
As we age, cells accumulate damaged proteins, dysfunctional organelles, and senescent "zombie" cells that poison their neighbors. This strategy focuses on clearing this biological debris.
Key Approaches
- Senolytics to eliminate senescent cells
- Autophagy induction through fasting and compounds
- Lipofuscin removal protocols
- Advanced glycation end-product (AGE) reduction
Debug the Code
Repair DNA and epigenetic damage
DNA damage accumulates with age, and epigenetic marks that control gene expression become dysregulated. This strategy aims to restore youthful genetic function.
Key Approaches
- Epigenetic reprogramming
- DNA damage repair enhancement
- Telomere lengthening protocols
- Gene therapy for aging genes
Restore the Power
Revitalize cellular energy production
Mitochondria are the power plants of cells, and they decline with age. This strategy focuses on restoring youthful mitochondrial function and cellular energy.
Key Approaches
- NAD+ precursor supplementation
- Mitochondrial biogenesis activation
- Mitophagy enhancement
- CoQ10 and PQQ optimization
New Parts for People
Regenerate tissues and organs
Stem cells lose their regenerative capacity with age. This strategy harnesses stem cells and regenerative medicine to replace worn-out tissues.
Key Approaches
- Stem cell therapy and banking
- Tissue engineering
- Platelet-rich plasma (PRP) treatments
- Exosome therapy
Optimize the Network
Restore intercellular communication
Cells communicate through hormones, growth factors, and signaling molecules. Aging disrupts these signals. This strategy restores youthful communication.
Key Approaches
- Peptide therapy protocols
- Hormone optimization (DHEA, pregnenolone)
- Growth factor modulation
- Inflammatory pathway management
Strengthen the Structure
Repair extracellular matrix damage
The scaffolding between cells (extracellular matrix) stiffens and deteriorates with age, affecting all tissues. This strategy restores structural integrity.
Key Approaches
- Collagen and elastin restoration
- Glycation cross-link breaking
- ECM remodeling protocols
- Skin and connective tissue support
Balance the System
Restore metabolic and immune homeostasis
Aging disrupts metabolic health and immune function. This strategy rebalances these critical systems to youthful setpoints.
Key Approaches
- Insulin sensitivity optimization
- Immune system rejuvenation
- Microbiome restoration
- Circadian rhythm optimization
Integrated Approach
Synergistic, Not Sequential
These seven strategies are not implemented in isolation or sequence. The most effective longevity protocols combine multiple approaches simultaneously, creating synergistic effects that amplify healthspan gains.
Personalized Application
Through deep biomarker testing, we identify which strategies are most relevant for each individual's unique aging profile. Not everyone needs the same interventions at the same time.
Evidence-Based Evolution
As longevity science advances, we continuously update our protocols based on the latest peer-reviewed research. This framework provides structure while remaining adaptable to new discoveries.
Learn How to Apply This Framework
Our education programs teach healthcare professionals how to implement these strategies in clinical practice.